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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Glycerophospholipid-driven lipid metabolic reprogramming as a common key mechanism in the progression of human primary hepatocellular carcinoma and cholangiocarcinoma

Fig. 2

Untargeted LC‒MS metabolomics analysis of primary cholangiocarcinoma. A Volcano plot of the Ctrl and CCA groups. B Hierarchical clustering analysis of the Ctrl and CCA groups. C Unsupervised PCA score plots of metabolomic phenotypes between the CCA and Ctrl groups. Model parameter: R2X = 0.801 (cumulative variance proportion of 2 principal components). D Score plot of the OPLS-DA model to maximize intergroup differentiation of the metabolomic data between the Ctrl and CCA groups. Model parameter: 1 predictive component + 1 orthogonal component, R2Y = 0.787, Q2 = 0.671. E OPLS-DA permutation test diagram of the Ctrl and CCA groups. F ROC plot of the OPLS-DA model differentiating the Ctrl and CCA groups. G Hierarchical clustering heatmap of differentially abundant metabolites between the Ctrl and CCA groups. H Correlation heatmaps of differentially abundant metabolites between the Ctrl and CCA groups. I KEGG pathway enrichment diagram for the Ctrl and CCA groups

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Lipids in Health and Disease

ISSN: 1476-511X