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Table 2 Association between fat distribution and AGP level among American adult female from the National Health and Nutrition Examination Survey 2015–2018

From: The association between fat distribution and α1-acid glycoprotein levels among adult females in the United States

Exposure

Non-adjusted

Adjust Ia

Adjust IIb

 

β (95%CI)

P value

β (95%CI)

P value

β (95%CI)

P value

BMI (kg/m**2)

Continuous

1.43 (1.33, 1.52)

 < 0.0001

1.37 (1.26, 1.48)

 < 0.0001

1.31 (1.18, 1.45)

 < 0.0001

Tertile:

 13.8–23.6

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 23.7–30.5

11.97 (10.09, 13.85)

 < 0.0001

11.31 (9.09, 13.53)

 < 0.0001

9.55 (6.93, 12.17)

 < 0.0001

 30.6–72.6

26.47 (24.57, 28.36)

 < 0.0001

25.75 (23.47, 28.04)

 < 0.0001

23.65 (20.90, 26.40)

 < 0.0001

 P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

TPF (%)

 Continuous

1.88 (1.75, 2.00)

 < 0.0001

1.93 (1.78, 2.07)

 < 0.0001

1.72 (1.55, 1.89)

 < 0.0001

Tertile:

 15 – 34.4

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 34.5 – 40.8

14.40 (12.33, 16.47)

 < 0.0001

15.41 (12.99, 17.83)

 < 0.0001

13.15 (10.38, 15.92)

 < 0.0001

 40.9—56.1

28.80 (26.73, 30.87)

 < 0.0001

29.43 (26.97, 31.89)

 < 0.0001

25.91 (23.02, 28.80)

 < 0.0001

 P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

APF (%)

 Continuous

1.43 (1.34, 1.53)

 < 0.0001

1.47 (1.37, 1.58)

 < 0.0001

1.30 (1.17, 1.43)

 < 0.0001

Tertile:

 11.9—33.8

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 33.9 – 42

13.47 (11.46, 15.48)

 < 0.0001

14.84 (12.50, 17.18)

 < 0.0001

12.70 (10.05, 15.36)

 < 0.0001

 42.1—58.8

28.39 (26.38, 30.40)

 < 0.0001

28.98 (26.65, 31.31)

 < 0.0001

25.21 (22.49, 27.93)

 < 0.0001

 P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

GPF (%)

 Continuous

1.82 (1.66, 1.98)

 < 0.0001

1.78 (1.60, 1.96)

 < 0.0001

1.59 (1.39, 1.79)

 < 0.0001

Tertile:

 16.6 – 39

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 39.1 – 43.8

12.22 (10.10, 14.34)

 < 0.0001

12.83 (10.42, 15.25)

 < 0.0001

10.91 (8.25, 13.58)

 < 0.0001

 43.9—61.9

23.07 (20.94, 25.19)

 < 0.0001

22.50 (20.05, 24.94)

 < 0.0001

19.65 (16.96, 22.34)

 < 0.0001

 P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

AGR (%)

      

 Continuous

0.75 (0.69, 0.81)

 < 0.0001

0.75 (0.68, 0.82)

 < 0.0001

0.62 (0.53, 0.71)

 < 0.0001

Tertile:

 15.37 –33.67

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 33.68 –45.16

13.34 (11.24, 15.43)

 < 0.0001

15.25 (12.82, 17.68)

 < 0.0001

13.42 (10.66, 16.18)

 < 0.0001

 45.17—107.47

24.76 (22.67, 26.86)

 < 0.0001

26.10 (23.58, 28.62)

 < 0.0001

21.14 (18.16, 24.12)

 < 0.0001

 P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

VPF (%)

 Continuous

11.43 (9.65, 13.20)

 < 0.0001

12.53 (10.17, 14.89)

 < 0.0001

8.58 (5.90, 11.25)

 < 0.0001

Tertile:

 0.039 – 0.96

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 0.97—1.39

8.00 (5.66, 10.34)

 < 0.0001

9.06 (6.28, 11.84)

 < 0.0001

7.80 (4.71, 10.89)

 < 0.0001

 1.40 – 4.22

14.53 (12.21, 16.85)

 < 0.0001

16.72 (13.62, 19.82)

 < 0.0001

12.49 (9.08, 15.90)

 < 0.0001

 P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

SPF (%)

 Continuous

3.74 (2.62, 4.86)

 < 0.0001

3.75 (2.51, 4.99)

 < 0.0001

2.79 (1.48, 4.11)

 < 0.0001

Tertile:

 3.95 – 6.00

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ref

 

ref

 

 6.01 – 6.75

5.63 (3.25, 8.01)

 < 0.0001

6.11 (3.45, 8.77)

 < 0.0001

4.89 (2.06, 7.73)

0.0007

 6.76—9.36

7.49 (5.11, 9.87)

 < 0.0001

7.80 (5.16, 10.44)

 < 0.0001

5.69 (2.89, 8.49)

 < 0.0001

 P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

VSR (%)

 Continuous

0.62 (0.51, 0.73)

 < 0.0001

0.65 (0.50, 0.79)

 < 0.0001

0.41 (0.26, 0.57)

 < 0.0001

Tertile:

 0.53 – 15.35

ref

 

ref

 

ref

 

 15.36—21.28

3.22 (0.95, 5.49)

0.0055

3.48 (0.79, 6.17)

0.0113

2.69 (-0.30, 5.67)

0.0777

 21.29 – 65.83

11.42 (9.16, 13.67)

 < 0.0001

12.18 (9.19, 15.18)

 < 0.0001

9.35 (6.11, 12.59)

 < 0.0001

 P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

  1. Abbreviations: AGP α1 acid glycoprotein, BMI Body mass index, TPF Total Percent Fat (%), APF Android percent fat (%), GPF Gynoid percent fat (%), AGR Android/Gynoid ratio (%), VPF Visceral percent fat (%), SPF Subcutaneous percent fat (%), VSR Visceral/Subcutaneous ratio (%)
  2. aModel I: Adjust for: age; race; education; marital status; ratio of family income to poverty
  3. bModel II: Adjust for: age; race; education; marital status; ratio of family income to poverty; physical activity; energy intake(kcal); smoke status; high blood pressure or not; high cholesterol level or not; diabetes or not; albumin (g/dL); total Cholesterol(mg/dL); triglycerides (mg/dL)
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Lipids in Health and Disease

ISSN: 1476-511X