Table 2 Fold change (median) of genes after 4 weeks intervention with a mixture of c9t11 and t10c12 CLA, c9t11 CLA, and t10c12 CLA compared to control (LA) according to realtime PCR verification.

Gene symbol [NCBI RefSeq]

all

Pro

Ala

all

Pro

Ala

all

Pro

Ala

Fatty acid transport and metabolism

PPARγ dependency

   ABCA9 [NM_080283.3]

-1.3*

-1.3*

-1.4*

n/a

   LDLR [NM_000527.3]

1.2**

1.8**

1.5**

1.5**

↑[85]

   CD36 [NM_001001547.1]

-1.2*

-1.6*

-1.3*

-1.2*

↑[65, 86]

   LIPE [NM_005357.2]

1.96†

1.8†

↑[23]

   CA3 [NM_005181.2]

-2.0**

-2.0*

n/a

   FASN [NM_004104.4]

1.5*

1.2*

1.4*

↑[87]

   SCD [NM_005063.4]

1.3*

1.5*

1.9*

↑[34, 88]

   FADS1 [NM_013402.3]

1.6*

1.6*

n/a

Transkription factors

   PPARG [NM_138711.3]

-1.4**a

1.3 b

   NFAT5 [NM_138713.2]

-1.5*

-1.6*

-1.6*

-1.9†

n/a

   CREB5 [NM_182899.3]

-1.5*

-1.9†

n/a

   EBF1 [NM_024007.3]

-1.5†

↑[89]

Adipokines

   ADIPOQ [NM_004797.29]

1.6†

1.5†

↑[90, 91]

   LEP [NM_000230.2]

-1.2 a

1.7†b

↓[92]

   NAMPT [NM_005746.2]

-1.6*

= [62]

   THBS1 [NM_003246.2]

1.5**

1.3*

1.5*

↓[64] ↑[65]

Insulin signaling

   IGF1 [NM_001111284.1]

-1.5†

-1.2**

-1.2*

↓ [93]

   SLC2A4 [NM_001042.2]

1.3*

1.5†

↑[94]

   SORBS1 [NM_001034954.1]

-1.2*

↑[74]

   PIK3R1 [NM_181523.1]

-1.6†

↑[95]

Others

   HPGD [NM_000860.3]

-1.3**

-1.4**

-1.6*

See text

   API5 [NM_006595.2]

-1.3†

-1.5*

n/a

   CD74 [NM_001025158.1]

1.2*

n/a

   UCP2 [NM_003355.2]

1.14*

1.8†

↑[79]

   IL6ST [NM_175767.1]

-1.3*

-1.5†

-1.8†

n/a