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Figure 2 | Lipids in Health and Disease

Figure 2

From: Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-α both in vitro and in vivo systems

Figure 2

Increased insulin production by INS-1 cells treated with TNF-α and oleic acid. (A) INS-1 cells were pre-treated for two hours with varying concentrations of oleic acid in medium containing 11 mM glucose, followed by TNF-α (100 pg/mL) treatment for 18–24 hrs at 37°C. Shown is one representative experiment with triplicate values out of three independent experiments.*, p < 0.05 for cells treated with TNF-α compared to cells treated with TNF-α and 10 μM or 5 μM oleic acid. (B) Cells were pre-treated for two hours with varying concentrations of oleic acid in medium containing 25 mM glucose, followed by TNF-α (100 pg/mL) treatment for 18–24 hrs at 37°C. Shown is one representative experiment with triplicate values out of three independent experiments. *, p < 0.05 for cells treated with TNF-α compared to cells treated with TNF-α and 10 μM or 5 μM oleic acid.

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Lipids in Health and Disease

ISSN: 1476-511X